Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi
نویسندگان
چکیده
منابع مشابه
Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.
Glutathione transferases are a multigene family of proteins that catalyze the conjugation of toxic electrophiles and carcinogens to glutathione. Glutathione transferase Pi (GSTP) is commonly overexpressed in human tumors and there is emerging evidence that the enzyme has additional cellular functions in addition to its role in drug and carcinogen detoxification. To investigate the unique functi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0911351106